᠓ Ticker: The Quest to Create an Artificial Heart online ᠢ Ebook Author Mimi Swartz ᢜ ᠓ Ticker: The Quest to Create an Artificial Heart online ᠢ Ebook Author Mimi Swartz ᢜ 1The Wizard, 2015Bud Frazier sometimes wandered through St Lukes Hospital like a large wraith in a white coat For decades he had traveled from his office in the Texas Heart Institute through the maze of attached hallways that was St Lukes, a worn paperback perpetually open in his hand, often something by Shakespeare, rarely anything that could remotely be considered popular At seventy five, Bud had earned certain privileges The right to walk and read, which kept a lot of people out of his way The right to leave towels in swirls and eddies on the floor of the private bathroom in his office The right to check his cellphone at society galas, because people assumed he was checking on patients, and sometimes he was A few years back, Bud had had to give up his black cowboy boots for running shoes, because surgery, especially lengthy surgeries, could be as hard on your legs and your back as it was on your hands Hed had two brand new titanium knees put in last summer and had been glad when he was able to give up the fancy cane hed had to use It made pretty women solicitous, which made him grouchy.Buds wife, Rachel, liked to describe her husband, generously, as an absentminded professor, but like many people at the top of their fields, Bud had lots of folks looking after the mundane details of his life so that he could focus on his work Bud often forgot his wallet he did not balance his checkbook he did not do email Once, when he could not find a parking place for a gala, he parked his old Jaguar XKE a gift from a grateful patient on the front patio of the Houston Museum of Natural Science, barely missing the fountains Everyone forgave him his trespasses Bud could list, among a very long list of friends and associates and patients and their family members, everyone from Mehmet Oz to the memoirist Mary Karr, from Dick Cheney to Bono, from Olivia de Havilland to various Middle Eastern and European royalty He had a long suffering assistant named Libby Schwenke who was charged with getting him from point A to point B, whether it was from Houston to Kazakhstan or just across the Texas Medical Center, which, unfortunately for her, was the largest in the world Even so, Bud was perennially late, famous for slipping into a party or a lecture long after it was in progress, which allowed him to be simultaneously unobtrusive and a center of attention Time for Bud was negotiable after so many years operating on the very sick, who didnt follow schedules either.So here he was, at the crack of dawn, alone Docs a lot younger than Bud, with better knees but slower hands, were still at home next to their sleeping wives at five thirty in the morning Whether he could admit it or not, Bud preferred his office to his home, surrounded by the books that were always in danger of tumbling off the shelves valuable first editions and ratty paperbacks Plutarch, Dickens, Dostoyevsky, a few nods to the likes of Hilary Mantel and Larry McMurtry His literary tastes were a lot high minded than those of the average medical student rotating through the Texas Heart Institute, a fact he sometimes couldnt resist noting to his med students When it came to literature, Bud was an equal opportunity snob introduced to U2 frontman Bono by a wealthy friend, Bud was appalled when the Irish rock star didnt immediately recognize some lines Bud recited from Yeats Bud opened the door and stepped into the outer office, with the bank of secretarial cubicles on one side and a wall of framed photos and clippings on the other Because there wasnt any natural light here, the pictures were as fresh as the day they had been taken photos of Bud with his mentors, Dr Michael DeBakey and Dr Denton Cooley, who had been among the most famous heart surgeons of their day in the years from 1960 to 1980 or so In another photo, Bud posed with Christiaan Barnard, the South African surgeon who had shocked the world and set off major envy attacks among his colleagues by performing the first human heart transplant in 1969 There was a photo of Bud with the longest living heart transplant patient in the world his patient and next to it a twenty year old story from the New York Times about the success of the left ventricular assist device Bud had an impressive collection of medals, and on the highest shelf above his assistants desk, a tenuously crowded collection of crystal vases and plaques etched with his name There was a framed portrait with a quote from Teddy Roosevelt a favorite of many aggrieved surgeons about the man in the arena who, if he fails, fails while daring greatly, so that his place shall never be with those cold and timid souls who neither know victory nor defeat Close to that was another maxim No one gets in to see the Wizard, not nobody, not no how, a former student had written, quoting the Wizard of Oz It was an inside joke Everyone got in Bud Frazier was incapable of telling anyone no.He padded down the dim hallway, past the open door to Billy Cohns office, the heart surgeon who sometimes helped Bud who was not mechanically minded develop devices for ailing hearts As often happened, Billy wasnt there he spent weeks in other countries, testing and lecturing on his many inventions But even when Billy was gone, his office seemed to be fully inhabited by him, by the whirs and clicks of all sorts of tiny machines that entranced him, by the perpetual motion of his screen savers on at least three computers and laptops, by the eerie blue light they projected around the room Billy hung his oldest prototypes on the walls with regular nails and thumb tacks and sometimes, Scotch tape a bent fork, a lariat made of thin white tubing, a kitchen spatula all variants of things he had invented that went into peoples bodies or helped heart surgeons do their jobs Buds office walls were paneled and book lined Billy filled his space with trinkets, doodads, and gewgaws that only he fully understood There were the books on magic piled on top of medical texts and a deck of cards on his desk Billy performed at national conventions There was a cover photo from a weekly tabloid of Billy playing the trombone with his band at a bar called the Boondocks, a late night date he kept every Tuesday This was a man whose fingers were still only when he was sleeping if in fact Billy ever slept Unlike Bud, Billy didnt keep a couch in his office.Bud left his office suite and made for the elevators He didnt stop on the ground floor, where he might have taken in his first exposure of the day to natural light it poured into the three story atrium of the Heart Institutes Denton A Cooley wing, as if God himself were blessing the place Instead, Cooley officed just behind the soaring space at ninety two, he still came in every day, getting around the hospital on a scooter or being pushed in a wheelchair by one of his former nurses Fortunately, he was not such a bad driver.At an elevator, Bud punched the button for the basement.In the old days the sixties, seventies, the early eighties the animal research lab had been on the third floor of St Lukes, adjacent to the operating rooms Such a location would be unethical now who would even think of it but back then laws on animal research were lax, and, besides, if Cooley wanted it there so he could duck in and out between surgeries, he got whatever he wanted because hed founded the heart institute for starters, and he brought in the most patients, meaning, of course, he brought in the most money The biggest problem with that location was that the obstetrics ward was also on the same floor, so the moans of women in labor were accompanied by the sounds of dogs barking, cows mooing, or the screeching of baboons.The end of that situation came with what Bud still called The Incident of the Yucatan Mini Pigs He had been working on some experiments that involved welding blood vessels together with lasers, and it turned out the veins of the 100 pound pigs were the closest things to humans But then someone snuck in one night and freed pigs from their cages probably an administrator, Bud still speculated darkly so about twenty of them went racing into the maternity ward Bud had to round up the mini pigs himself, herding them back into the lab as they snorted and relieved themselves all over the place Soon after that, Cooley got a new cardiac research lab in the basement.Bud had been in charge for the last forty years or so.The door to the lab had a window covered with a venetian blind, a nod to security along with the key card Bud swiped to let himself in The place wasnt much to look at, which made it camera ready for PETA membership drives The floor was linoleum, and the tile walls were that sorry shade of prison green The animals in metal stanchions like modern day stocks raised their heads to look at Bud one goat, one cow At his arrival they blinked and chewed the hay at their feet, paying him little mind.He had told his mother, a schoolteacher, that hed decided to become a doctor one night while she was cooking him dinner He was in from Austin and the University of Texas, back home in the small town of Stephenville She kept stirring a pot on the stove while he explained his choice she didnt stop to look at him Well, she said, when he finished, I think you should do what you want, but I never knew you to much like to kill things Well, killing things wasnt his goal as a doctor, but being an attentive son Bud intuited her meaning with a mothers impeccable memory, she was referencing that time he was eight years old and his friend Butch Henry had shot a rabbit in the brush Bud raced to the site and found a mother rabbit dying, her unborn babies tumbling out of her belly where the shotgun pellets had torn her open Bud gathered up the tiny bundle of kits, raced home and tried to save them, but he was too late.His lifes through line became saving the unsavable This made Bud not just famous and respected, but beloved, and not just in Houston but anywhere he had taken care of sick people around the world But he still had one goal to accomplish before he hung it up Bud wanted to see a working artificial heart become a reality, a total replacement that could be implanted and then forgotten, as his frenemy, another famous heart surgeon, Robert Jarvik liked to say And, finally, Bud felt that he was close.In the next room, Bud found the calf He was a Corriente, a smallish breed descended from the Spanish His coat was a reddish brown, soft and thick in a different life he would have spent his youth avoiding cowboys in a roping competition at a rodeo Instead, he was standing up in his small stall, wires and tubes running in and out of his chest every which way, hooked up to enough monitors better suited to a moon shot Bud scratched the calfs forehead and thought, as he often did, that they were such sweet animals.Nearby, on a pile of old hospital blankets, was Dr Daniel Timms, who had been sleeping there all night A youthful looking thirty five year old biomedical engineer from Brisbane, Australia, Timms was a slight, tightly wound man with piercing blue eyes and a snaggletooth that, depending on which nurse you asked, made him or less movie star handsome His short brown hair was often tousled, and he always seemed in need of a shave Daniel wasnt known around the THI for his sense of humor, but the rumors of his genius gave him a pass.The calf shifted its weight and Daniels eyes followed, watching the animals chest move in and out Then, reflexively, Daniels eyes moved to the monitor It registered the calfs vital signs as completely normal.Or rather, completely normal considering that yesterday, in an eight hour operation, Drs Frazier and Cohn had sliced out the calfs heart and replaced it with Daniel Timms invention, a device smaller than a tennis ball, that, once stitched in place, took over all the functions of a normal heart Except, that is, for one thing the calf had no detectable pulse One small titanium disc spinning in its housing at four thousand times a minute was the only thing keeping this calf alive.2How Hard Could It Be Deep in the bowels of the Smithsonian Institutions National Museum of American History is a section of a storeroom with a particular set of drawers If you go through the proper channels, a friendly curator will let you in and, donning a pair of gloves, open the drawers to reveal some very strange and pretty unappealing looking devices Some are made of plastic faded to the color of old chicken broth though thats a nice way of putting it Others contain discolored tubes and fabric stained the color of rust, or, precisely, old blood Virtually all of them have two parts stuck together one heart is connected with Velcro Most have large holes on each side, giving them the look of cockeyed binoculars.They do not look like anything a sane person would want stuck inside him or herself But in fact these devices represent what has been, for a very long time, the holy grail of medicine a dependable artificial heart that works on its own inside the body, just like an artificial hip or knee The cure for cancer runs a very close second to this pursuit, but the fact is, heart disease kills people around the world than all cancers combined 17.9 million people or 32 percent of all deaths in 2015 Three million women in the United States had breast cancer last year, while 12 million had heart disease And while these numbers are declining in the developed world, about 26 million Americans currently have heart disease 2,150 of them die of it each day, an average of one death every forty seconds, or one out of every six deaths in the United States The number of people who die from heart attacks may have also fallen significantly over the years, thanks to better care and better technology, but now a greater problem is heart failure, a chronic, progressive illness interrupted with life threatening crises The American Heart Associations figures show that 5.7 million people suffered from heart failure in the period from 2009 to 2012, but that number jumped to 6.5 million, a 14 percent increase, from 2012 to 2014 Heart transplants have become the solution of choice for disease that is beyond treatment with diet, lifestyle, and medication, but surgeons and their desperate patients know the truth in any given year there were only 2,500 hearts available for transplant, with about 50,000 people on the waiting list In other words, there are twenty times losers than winners.A pacy, blow by blow account of the search for a viable artificial heart Swartz offers a vivid gallery of the medical pioneers who have jostled for the prize Nature.com Tickeris beautifully and ingeniously constructed, flowing like a fast paced science fiction novel, engendering wide eyed wonder at a remarkable, smart, compelling, and very human story at the busy intersection of money, politics, law, science, medicine, ethics, and philosophy Lone Star Literary ReviewA riveting medical thrillerTold in an appropriately over the top style, this is a quintessentially Texas story sprawling, unpredictable, and teeming with risk and opportunity Publishers WeeklyEven casually interested readers will become fascinated by Swartz s vivid depiction of Frazier at work in the operating roomSwartz is a witty, savvy, seasoned journalist, and she offers a welcome history of significant medical advances Kirkus ReviewsSmart, compelling, and completely engaging, Ticker is a story about science, personality, innovation, and obsession, all in pursuit of a staggering accomplishment, the creation of an artificial heart Mimi Swartz drives the narrative with great style and deep reporting its a book anyone with a heart will love Susan Orlean, author of Rin Tin Tin The Life and the Legend and The Orchid Thief A remarkable journey through the harrowing world of heart surgery, as a brilliantly gifted and eccentric team of doctors work to develop a complete artificial heart, to save the thousands of patients a year whose hearts are failing Bryan Burrough, author of Public Enemies, The Big Rich and Barbarians at the Gate Ticker is like a medical version of Tom Wolfe s The Right Stuff Swartz takes you into the operating theater with some of the most brilliant, ingenious and driven heart specialists in the world It s a book full of memorable characters grappling with life threatening crises, which is both illuminating about modern medicine, and also just a wonderful read Jane Mayer, author of Dark Money Ticker is a page turner, a mind expander, a heart pounder Swartz unveils a wild story of medical innovation with the keen eye of a storyteller David Eagleman, Stanford University neuroscientist and internationally bestselling authorof The Brain and Incognito A fast paced, utterly riveting tale of the decades of effort that have gone into developing an artificial heart The characters, many of whom dedicated their lives to this quest, are captivating, and their rivalries are the stuff of legend Bethany McLean, co author of All the Devils Are Here and The Smartest Guys in the Room A thrilling and affecting account of a modern medical miracle Ticker is not only an inspiring tale of persistence, imagination, and sacrifice, its also a joy to read Lawrence Wright, Pulitzer Prize winning author of The Looming Tower and God Save Texas Who knew that the story of the artificial heart was such a rip roaring one, with one larger than life character after another, and plot twists galore In Ticker, Mimi Swartz has told that story with verve and elegance, and brought those characters to vivid life A wonderful work of nonfiction by a wonderful nonfiction writer Joe Nocera, Bloomberg News columnist and author of Indentured The Inside Story of the Rebellion Against the NCAA An exciting, propulsive, and at times surprisingly tender account of the swashbuckling surgeons and inventive geniuses who achieved one of the greatest medical breakthroughsthe development of the artificial heart Mimi Swartz has done an outstanding job, and uncovered the human story behind the triumph of technology Jennet Conant, New York Times bestselling author of Tuxedo Park and 109 East Palace Invesco Product Detail Exchange Traded Funds During the weekend of August , our third party Administrator The Bank New York Mellon BNYM experienced a technical malfunction resulting in it being unable to calculate timely NAVs for its mutual funds and ETF clients, including PowerShares ETFs BC Wikipedia BC may refer Before Christ, an epoch used dating years prior estimated birth Jesus Julian Gregorian calendars SXE Quote EURO STOXX Price EUR Index Bloomberg Markets Index, Europe s leading blue chip index Eurozone, provides representation supersector leaders region covers stocks from Eurozone Ticker eBook Lisa Mantchev Kindle Store edition by Download 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