ᥗ eTextbook ᙙ The Organic Chemistry of Drug Design and Drug Action store ᦖ E-Pub Author 54 offers from ᧂ ᥗ eTextbook ᙙ The Organic Chemistry of Drug Design and Drug Action store ᦖ E-Pub Author 54 offers from ᧂ The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters, including new examples and references It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage. This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry research chemists and biochemists working in pharmaceutical and biotechnology industries.Updates to all chapters, including new examples and referencesChapter 1 Introduction Completely rewritten and expanded as an overview of topics discussed in detail throughout the bookChapter 2 Lead Discovery and Lead Modification Sections on sources of compounds for screening including library collections, virtual screening, and computational methods, as well as hit to lead and scaffold hopping expanded sections on sources of lead compounds, fragment based lead discovery, and molecular graphics and deemphasized solid phase synthesis and combinatorial chemistryChapter 3 Receptors Drug receptor interactions, cation and halogen bonding atropisomers case history of the insomnia drug suvorexantChapter 4 Enzymes Expanded sections on enzyme catalysis in drug discovery and enzyme synthesisChapter 5 Enzyme Inhibition and Inactivation New case histories for competitive inhibition, the epidermal growth factor receptor tyrosine kinase inhibitor, erlotinib and Abelson kinase inhibitor, imatinibfor transition state analogue inhibition, the purine nucleoside phosphorylase inhibitors, forodesine and DADMe ImmH, as well as the mechanism of the multisubstrate analog inhibitor isoniazidfor slow, tight binding inhibition, the dipeptidyl peptidase 4 inhibitor, saxagliptinChapter 7 Drug Resistance and Drug Synergism This new chapter includes topics taken from two chapters in the previous edition, with many new examplesChapter 8 Drug Metabolism Discussions of toxicophores and reactive metabolitesChapter 9 Prodrugs and Drug Delivery Systems Discussion of antibody drug conjugates The Organic Chemistry Tutor YouTube This channel focuses on providing tutorial videos organic chemistry, general physics, algebra, trigonometry, precalculus, and calculus Organic American 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